DNA Signature – Suite of Tests

Buccal Swab

Turnaround Time: First test with initial sequencing: 2-3 weeks; All subsequent tests: 48 hours.

Turnaround times are estimates. Detailed order tracking is available in the MosaicDX Portal.

Sample Reports | Test Prep and Instructions

* Available in English

FAQs

Going Beyond SNPs. Polygenic Risk Scoring for a More Personalized Path Forward.

DNA Signature, a next-generation suite of genomic profiles, looks beyond individual variants, combining polygenic risk scoring with clinical interpretation to translate complex genetics into personalized strategies for better health.

DNA Signature translates complex SNP data into a clear, prioritized hierarchy of modifiable levers. Instead of broad recommendations or trial-and-error protocols, you get targeted guidance on:

Specific Foods & Nutrients: Tailored dietary changes and precision supplementation.
Lifestyle & Exercise: Custom habits aligned with the patient’s genetic stress and recovery responses.
Targeted Functional Testing: Clear guidance on which follow-up labs will yield the highest clinical value.

Five DNA Signature profiles, each designed to deliver personalized, actionable insights:

DNA Signature – Metabolic Path Evaluates foundational genomic variations governing cellular energy production, nutrient utilization, neurotransmitter balance, gut health, methylation/detoxification, and nutrient needs.
DNA Signature – Toxins Evaluates key genetic variations governing environmental toxin clearance, oxidative stress response, and essential methylation pathways.
DNA Signature – Wellness Provides a comprehensive genomic blueprint of foundational vitality, metabolic potential, physical performance, and biological aging trajectory. By evaluating interconnected pathways governing cellular energy, this panel pinpoints an individual’s unique physiological capacity.
DNA Signature – Spectrum Map A specialized genomic tool engineered to evaluate the interconnected biochemical pathways influencing neurodivergent traits, including Autism Spectrum conditions, ADHD, executive function variations, and sensory processing differences.
DNA Signature – Mind & Mood Provides a targeted genomic evaluation of emotional regulation, cognitive longevity, stress resilience, and sleep architecture and provides insight into the baseline biochemical drivers behind mood and cognitive health.

Practitioners:

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For Non-Practitioners:

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What Patients Might Benefit from DNA Signature Testing?

Patients with the following symptoms or conditions may benefit from DNA Signature testing

Complex Chronic Diseases
Wellness Optimization
ASD
Neurodivergent,
Metabolic Syndrome
Fatigue
Malaise
Mood Disorders
Cognitive Risk / Disorders
Neurodegenerative Disease / Risk
Oxidative Stress
Chronic Inflammation
Toxin Exposures

Details

Why Use DNA Signature Profiles?

True Systems Biology: A single isolated SNP tells you very little, the body operates through complex, interwoven biochemical networks. This test evaluates how groups of genes interact across metabolic pathways (such as inflammation, methylation, detoxification, energy production, and stress resilience). By utilizing polygenic scoring and pathway analysis rather than looking at isolated mutations, it reflects how your body actually functions in a dynamic system. A single isolated SNP tells you very little, the body operates through complex, interwoven biochemical networks. This test evaluates how groups of genes interact across metabolic pathways (such as inflammation, methylation, detoxification, energy production, and stress resilience). By utilizing polygenic scoring and pathway analysis rather than looking at isolated mutations, it reflects how your body actually functions in a dynamic system.

High Evidence Bar & Clinical Relevance: Not all genetic data is worth acting on. Every SNP included is mapped against a continuously updated, peer-reviewed library validated for clinical significance (evaluating study replication, population data, and odds ratios). You receive only research-backed, clinically meaningful insights. Not all genetic data is worth acting on. Every SNP included is mapped against a continuously updated, peer-reviewed library validated for clinical significance (evaluating study replication, population data, and odds ratios). You receive only research-backed, clinically meaningful insights.

Root-Cause Insights: When standard bloodwork appears within normal reference ranges, individual genetic variations can still significantly alter underlying biochemistry. By evaluating functional pathways, such as energy production, metabolic rate, inflammation, oxidative stress, toxin sensitivity, and stress response mechanisms, this test looks beneath surface-level biomarkers to uncover the physiological drivers behind persistent functional imbalances.

Direct Bridge to Actionable Personalization: DNA Signature translates complex SNP data into a clear, prioritized hierarchy of modifiable levers. Instead of broad recommendations or trial-and-error protocols, you get targeted guidance on:
- Specific Foods & Nutrients: Tailored dietary changes and precision supplementation.
- Lifestyle & Exercise: Custom habits aligned with the patient’s genetic stress and recovery responses.
- Targeted Functional Testing: Clear guidance on which follow-up labs (such as OAT or TOXDetect) will yield the highest clinical value.

Our high-complexity laboratory is committed to delivering accurate and reliable results in coordination with these top licensure programs:

Sample Reports

DNA Signature – Metabolic Path Sample Test Reports (Sample Report)

Test Prep and Instructions

MosaicDX offers patient-friendly sample collection kits that simplify testing. Our kits include visual, step-by-step instructions for test preparation and sample collection, personalized shipping cards, and pediatric collection bags if needed. With MosaicDX, patients can easily collect samples for testing with confidence and accuracy.

DNA Signature Collection Instructions

Shipping Information Within the United States

Frequently Asked Questions

No, we do not. A genetic carrier refers to an individual who has inherited a recessive allele that has been shown to be responsible for an autosomal recessive disease or trait. A genetic carrier only has one recessive allele so while they do not show signs or symptoms of the trait or disease, they are able to pass along the recessive gene to their child. Our genetic testing is for screening purposes only to assess risk or predisposition for certain traits associated with health and wellness.

No. We do not use patient samples for further research or testing. We may use your de-identified and anonymized data to help improve our algorithm and reports. Your data will not be sold or shared to or with any 3rd parties/commercial interests.

Yes, we can delete the patient’s raw genetic sequence at any time. Please note that applicable federal and state laws require us to retain your patient report and the subset of your data that was used to generate that report for a specified period of time. We will be happy to delete any and all of your data that we are legally allowed to delete upon request. Please submit your request here.

We implement rigorous selection criteria when choosing which genes or SNPs to include in our panels. The selection and validation criteria are based upon peer-reviewed studies that show a significant association between the SNP variant and trait or condition, the magnitude of the odds ratio (OR) or hazard ratio (HR) to assess risk related to the variant, as well as the population or populations the gene and SNP variant were studied in, the population size, and replication of findings.

A genotype refers to the actual inherited genetic material of an individual that can influence or determine certain characteristics or traits. A phenotype is how the genotype is actually expressed, that is the observable or measurable characteristics or traits of an individual.

SNP is also called a Single Nucleotide Polymorphism. Your DNA consists of 4 main building blocks (nucleotides), Adenine (A), Thymine (T), Guanine (G), and Cytosine (C). In certain locations within your DNA, one person may have an A, whereas another may have a G. This difference in the base pair is often called a variant. This variant is an SNP.

In most situations, you do not have to resubmit a DNA buccal swab sample if you later want to order additional panels. The only time a new DNA buccal swab would need to be resubmitted is if the assay has had significant changes, or the patient previously requested that their DNA sequencing results be deleted.

Patients are sent a DNA Signature Collection Kit containing instructions, 1 cheek swab, a DNA Sample Envelope and a prepaid return envelope and biohazard zip-lock bag. Instructions can also be found on our website on the DNA Signature Profiles web page, along with an easy-to-follow video.

A person’s polygenic risk score is a statistical calculation based on the presence or absence of multiple genomic variants without taking environmental or other factors into account

Different states have regulations that define the scope of practice for practitioners. It is the practitioner’s responsibility to abide by these rules. Check with your state board of health to determine any restrictions related to laboratory testing. Please note, Mosaic Diagnostics does not offer testing in New York.

Once you have opened your account, you have the options of ordering kits to stock in your office or drop-ship kits directly to your patients through your MosaicDX portal.  

Watch our short tutorial videos on how to conveniently 

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DNA Signature – Suite of Tests