Going Beyond SNPs. Polygenic Risk Scoring for a More Personalized Path Forward.
DNA Signature, a next-generation suite of genomic profiles, looks beyond individual variants, combining polygenic risk scoring with clinical interpretation to translate complex genetics into personalized strategies for better health.
DNA Signature – Toxins evaluates key genetic variations governing environmental toxin clearance, oxidative stress response, and essential methylation pathways.
By assessing interconnected functional networks rather than isolated variants, such as potential mismatches between Phase I activation and Phase II clearance, DNA Signature – Toxins maps your baseline biochemical resilience and pinpoints subtle metabolic bottlenecks. The report provides a clear blueprint of modifiable pathways, empowering practitioners to deliver targeted dietary, lifestyle, nutrient and additional testing interventions before environmental burden manifests as functional imbalance.
Designed as the genetic companion to MosaicDX TOXDetect Profile®, MycoTOX Profile®, and Heavy Metals Profiles
This comprehensive panel evaluates key genetic variations that govern your body’s ability to neutralize environmental toxins, manage oxidative stress, and drive essential methylation/detoxification pathways. By looking beyond isolated variants to assess interconnected functional networks, this panel provides a clear blueprint of your baseline biochemical resilience and potential metabolic bottlenecks.
Core Functional Domains Evaluated
Phase I & Phase II Detoxification Efficiency
Phase I Biotransformation (CYP Enzymes): Assesses the speed and efficiency with which Cytochrome P450 enzymes begin converting fat-soluble compounds into intermediate metabolites.
Phase II Conjugation Pathways: Evaluates critical clearance routes that neutralize reactive intermediate toxins, including Glucuronidation (UGT enzymes) and NAT2 activity (acetylation).
Glutathione System & Antioxidant Defense: Measures genetic propensity for Glutathione production and overall Phase II detox efficiency, as well as NRF2 activity, the master regulator of cellular defense against Oxidative Stress.
Environmental & Chemical Sensitivity Profile
Synthetic & Industrial Chemicals: Evaluates genetic clearance capacity and susceptibility to household and industrial compounds, including BPA, Phthalates, Pesticides, VOCs, Pesticides, and general Chemical Sensitivity.
Heavy Metals & Environmental Elements: Maps susceptibility and processing efficiency related to inorganic exposure risks, specifically Arsenic, Mercury, Lead, and Fluoride.
Folate & Methionine Cycles: Evaluates foundational enzyme activity driving one-carbon flux, including MTHFR, MTR, and MTRR.
Cellular Methylation Capacity: Assesses AHCY activity and overall choline need to support phospholipid synthesis, liver export, and alternative re-methylation routes.
Neuro-Metabolic Regulation: Evaluates COMT activity to understand how methylation throughput directly impacts catecholamine breakdown and neuro-chemical balance.
Our high-complexity laboratory is committed to delivering accurate and reliable results in coordination with these top licensure programs:
Analytes
From a single easy-to-collect buccal swab you will receive a personalized polygenic risk score for the following traits:
General Chemical Sensitivity
Benzene Risk
Pesticide Risk
BPA Risk
Phthalate Metabolism (CYP2B6)
Mold Metabolism (CYP1A2)
Mold Severity Risk
Arsenic Exposure Risk
Mercury Exposure Risk
Lead Exposure Risk
Fluoride Exposure Risk
CYPs
Glucuronidation Activity
NAT2 Activity
NRF2 Activity
Glutathione Level Propensity
Oxidative Stress
Phase II Detox Efficiency
MTHFR Activity
MTR
MTRR
COMT (Methylation)
AHCY
Choline Need
Sample Reports
The DNA Methylation Profile report aids clinical support for patients by pinpointing SNPs that could potentially impact health and disease risk.
MosaicDX offers patient-friendly sample collection kits that simplify testing. Our kits include visual, step-by-step instructions for test preparation and sample collection, personalized shipping cards, and pediatric collection bags if needed. With MosaicDX, patients can easily collect samples for testing with confidence and accuracy.
No, we do not. A genetic carrier refers to an individual who has inherited a recessive allele that has been shown to be responsible for an autosomal recessive disease or trait. A genetic carrier only has one recessive allele so while they do not show signs or symptoms of the trait or disease, they are able to pass along the recessive gene to their child. Our genetic testing is for screening purposes only to assess risk or predisposition for certain traits associated with health and wellness.
No. We do not use patient samples for further research or testing. We may use your de-identified and anonymized data to help improve our algorithm and reports. Your data will not be sold or shared to or with any 3rd parties/commercial interests.
Yes, we can delete the patient’s raw genetic sequence at any time. Please note that applicable federal and state laws require us to retain your patient report and the subset of your data that was used to generate that report for a specified period of time. We will be happy to delete any and all of your data that we are legally allowed to delete upon request. Please submit your request here.
We implement rigorous selection criteria when choosing which genes or SNPs to include in our panels. The selection and validation criteria are based upon peer-reviewed studies that show a significant association between the SNP variant and trait or condition, the magnitude of the odds ratio (OR) or hazard ratio (HR) to assess risk related to the variant, as well as the population or populations the gene and SNP variant were studied in, the population size, and replication of findings.
A genotype refers to the actual inherited genetic material of an individual that can influence or determine certain characteristics or traits. A phenotype is how the genotype is actually expressed, that is the observable or measurable characteristics or traits of an individual.
SNP is also called a Single Nucleotide Polymorphism. Your DNA consists of 4 main building blocks (nucleotides), Adenine (A), Thymine (T), Guanine (G), and Cytosine (C). In certain locations within your DNA, one person may have an A, whereas another may have a G. This difference in the base pair is often called a variant. This variant is an SNP.
In most situations, you do not have to resubmit a DNA buccal swab sample if you later want to order additional panels. The only time a new DNA buccal swab would need to be resubmitted is if the assay has had significant changes, or the patient previously requested that their DNA sequencing results be deleted.
Patients are sent a DNA Signature Collection Kit containing instructions, 1 cheek swab, a DNA Sample Envelope and a prepaid return envelope and biohazard zip-lock bag. Instructions can also be found on our website on the DNA Signature Profiles web page, along with an easy-to-follow video.
A person’s polygenic risk score is a statistical calculation based on the presence or absence of multiple genomic variants without taking environmental or other factors into account
Different states have regulations that define the scope of practice for practitioners. It is the practitioner’s responsibility to abide by these rules. Check with your state board of health to determine any restrictions related to laboratory testing. Please note, Mosaic Diagnostics does not offer testing in New York.
Once you have opened your account, you have the options of ordering kits to stock in your office or drop-ship kits directly to your patients through your MosaicDX portal.
Watch our short tutorial videos on how to conveniently
