Going Beyond SNPs. Polygenic Risk Scoring for a More Personalized Path Forward.
DNA Signature, a next-generation suite of genomic profiles, looks beyond individual variants, combining polygenic risk scoring with clinical interpretation to translate complex genetics into personalized strategies for better health.
The DNA Signature – Wellness panel provides a comprehensive genomic blueprint of an individual’s foundational vitality, metabolic potential, physical performance, and biological aging trajectory.
By evaluating interconnected pathways governing cellular energy (Mitochondrial Function, Oxidative Stress, Telomere Length), macronutrient response (Glucose Metabolism, Protein Benefit), and physical resilience (Muscle Mass, Soft Tissue & Cartilage Risk, Recovery Speed), this panel pinpoints an individual’s unique physiological capacity. It translates complex genetic data into targeted dietary, exercise, and lifestyle interventions. Helping practitioners design proactive protocols to optimize athletic performance, prevent soft-tissue injury, and promote long-term vitality.
What Patients Might Benefit from DNA Signature – Wellness Testing?
Patients with the following symptoms or conditions may benefit from DNA Signature – Wellness testing
Athletes & Active Individuals Seeking Performance Optimization
Seeking Metabolic & Weight Optimization
Focused on Healthy Aging & Longevity
Struggling with Sleep, Fatigue, or Slow Exercise Recovery
Details
Why Use the DNA Signature – Wellness Profile?
The DNA Signature – Wellness Profile provides a comprehensive genomic blueprint of an individual’s foundational vitality, physical performance potential, metabolic efficiency, and long-term biological aging trajectory. By evaluating interconnected pathways across cellular energetics, musculoskeletal resilience, and lifestyle behaviors, this panel helps practitioners go beyond basic fitness or diet advice to design highly targeted, preventative lifestyle protocols.
Core Functional Domains Evaluated
Cellular Health, Aging & Longevity
Longevity & Biological Age: Assesses genetic propensity for longevity, telomere length maintenance, and structural APOE status to map baseline cellular aging and cardiovascular/neuro-metabolic resilience
Mitochondrial Output & Defense: Evaluates mitochondrial function, oxidative stress buffering capacity, and nitric oxide regulation for vascular flow and cellular oxygenation.
Metabolic & Dietary Response Profiles
Glycemic & Energy Efficiency: Maps glucose metabolism and complex carbohydrate utilization to optimize dietary macronutrient ratios.
Protein Dynamics & Micronutrients: Assesses individual protein benefit for lean tissue maintenance and identifies genetic risks in vitamin D3 conversion efficiency.
Physical Performance, Recovery & Tissue Integrity
Musculoskeletal Potential: Evaluates genetic capacity for muscle mass development and intrinsic exercise motivation.
Soft Tissue & Joint Resilience: Maps structural risk profiles for soft tissue and cartilage injury risk inform injury prevention strategies.
Recovery Dynamics: Measures baseline recovery speed post-exertion to optimize training volume and rest intervals.
Neuro-Systemic Adaptation & Sleep
Systemic Stress Handling: Assesses biological stress adaptation capacity to prevent burnout and overtraining.
The Wellness Panel translates complex genetic data into actionable, everyday lifestyle levers. Rather than recommending generic wellness advice, this panel equips practitioners to:
Optimize Training & Recovery: Tailor exercise programming, rest days, and soft-tissue injury prevention strategies based on the patient’s structural and metabolic recovery limits.
Personalize Macronutrient & Nutrient Strategies: Fine-tune carbohydrate intake, protein distribution, and targeted nutrients to support metabolic flexibility and cellular energy.
Support Long-Term Vitality: Implement targeted antioxidant, vascular, and lifestyle strategies designed to preserve telomere integrity, mitochondrial output, and healthy aging pathways.
Our high-complexity laboratory is committed to delivering accurate and reliable results in coordination with these top licensure programs:
Analytes
From a single easy-to-collect buccal swab you will receive a personalized polygenic risk score for the following traits:
Longevity Propensity
Mitochondrial Function
Telomere Length
APOE Status
Oxidative Stress
Nitric Oxid Regulation
Glucose Metabolism
Complex Carbohydrate Utilization
Protein Benefit
Vitamin D3 Risk / Conversion
Exercise Motivation
Muscle Mass
Recovery Speed
Soft Tissue Risk
Cartilage Risk
Stress Adaptation
Reported Sleep Quality
Sample Reports
The DNA Methylation Profile report aids clinical support for patients by pinpointing SNPs that could potentially impact health and disease risk.
MosaicDX offers patient-friendly sample collection kits that simplify testing. Our kits include visual, step-by-step instructions for test preparation and sample collection, personalized shipping cards, and pediatric collection bags if needed. With MosaicDX, patients can easily collect samples for testing with confidence and accuracy.
No, we do not. A genetic carrier refers to an individual who has inherited a recessive allele that has been shown to be responsible for an autosomal recessive disease or trait. A genetic carrier only has one recessive allele so while they do not show signs or symptoms of the trait or disease, they are able to pass along the recessive gene to their child. Our genetic testing is for screening purposes only to assess risk or predisposition for certain traits associated with health and wellness.
No. We do not use patient samples for further research or testing. We may use your de-identified and anonymized data to help improve our algorithm and reports. Your data will not be sold or shared to or with any 3rd parties/commercial interests.
Yes, we can delete the patient’s raw genetic sequence at any time. Please note that applicable federal and state laws require us to retain your patient report and the subset of your data that was used to generate that report for a specified period of time. We will be happy to delete any and all of your data that we are legally allowed to delete upon request. Please submit your request here.
We implement rigorous selection criteria when choosing which genes or SNPs to include in our panels. The selection and validation criteria are based upon peer-reviewed studies that show a significant association between the SNP variant and trait or condition, the magnitude of the odds ratio (OR) or hazard ratio (HR) to assess risk related to the variant, as well as the population or populations the gene and SNP variant were studied in, the population size, and replication of findings.
A genotype refers to the actual inherited genetic material of an individual that can influence or determine certain characteristics or traits. A phenotype is how the genotype is actually expressed, that is the observable or measurable characteristics or traits of an individual.
SNP is also called a Single Nucleotide Polymorphism. Your DNA consists of 4 main building blocks (nucleotides), Adenine (A), Thymine (T), Guanine (G), and Cytosine (C). In certain locations within your DNA, one person may have an A, whereas another may have a G. This difference in the base pair is often called a variant. This variant is an SNP.
In most situations, you do not have to resubmit a DNA buccal swab sample if you later want to order additional panels. The only time a new DNA buccal swab would need to be resubmitted is if the assay has had significant changes, or the patient previously requested that their DNA sequencing results be deleted.
Patients are sent a DNA Signature Collection Kit containing instructions, 1 cheek swab, a DNA Sample Envelope and a prepaid return envelope and biohazard zip-lock bag. Instructions can also be found on our website on the DNA Signature Profiles web page, along with an easy-to-follow video.
A person’s polygenic risk score is a statistical calculation based on the presence or absence of multiple genomic variants without taking environmental or other factors into account
Different states have regulations that define the scope of practice for practitioners. It is the practitioner’s responsibility to abide by these rules. Check with your state board of health to determine any restrictions related to laboratory testing. Please note, Mosaic Diagnostics does not offer testing in New York.
Once you have opened your account, you have the options of ordering kits to stock in your office or drop-ship kits directly to your patients through your MosaicDX portal.
Watch our short tutorial videos on how to conveniently
