Going Beyond SNPs. Polygenic Risk Scoring for a More Personalized Path Forward.
DNA Signature, a next-generation suite of genomic profiles, looks beyond individual variants, combining polygenic risk scoring with clinical interpretation to translate complex genetics into personalized strategies for better health.
DNA Signature – Spectrum Map is a specialized genomic tool engineered to evaluate the interconnected biochemical pathways influencing neurodivergent traits, including Autism Spectrum conditions, ADHD, executive function variations, and sensory processing differences.
By mapping genomic interactions across neuro-chemical balance, detoxification capacity, immune/histamine regulation, and nutrient metabolism, it provides practitioners with an objective blueprint of each patient’s unique physiological landscape. This panel helps clarify the underlying drivers behind common overlapping challenges, such as sleep disruptions, environmental sensitivities, GI issues, and altered nutrient processing, empowering clinicians to design highly targeted, personalized intervention strategies.
Designed as a genetic companion to MosaicDX Organic Acids Test (OAT) and EnviroTOX® Profiles
Multi-System Reactivity & High Environmental Sensitivity
Patients with Sleep Architecture Disruptions
Methylation & Neuro-Nutritional Bottlenecks
Details
Why Use the DNA Signature – Spectrum Map Profile?
DNA Signature – Spectrum Map is a specialized genomic tool designed to evaluate the interconnected biochemical pathways that influence neurodivergent traits, including Autism Spectrum conditions, ADHD, executive function variations, and sensory processing differences. By assessing how genomic variants across neuro-chemical, detoxification, immune, and metabolic pathways interact, this panel provides practitioners with an objective blueprint to better understand and support each patient’s unique physiological landscape.
Core Functional Domains Evaluated
Executive Function & Neuro-Chemical Balance
Attention & Cognitive Focus: Maps genetic variations associated with ADHD Propensity and Attention Regulation to help clarify underlying neuro-chemical dynamics.
Methylation & Neurotransmitter Support: Evaluates core Methylation Traits that drive central nervous system turnover, DNA repair, and the synthesis and breakdown of key neurotransmitters.
Biotransformation Pathways: Assesses Phase I and Phase II detoxification kinetics, including CYPs (Phase 1 detoxification), Glucuronidation, and overall detoxification capacity.
Pesticide & Chemical Clearance: Evaluates PON (Paraoxonase) activity, an enzyme vital for breaking down organophosphates, pesticides, and oxidized lipids.
Mast Cell & Histamine Dynamics: Maps genetic markers involved in histamine/mast cell activation, providing insight into neuro-inflammation, food/environmental sensitivities, and gut-brain reactivity.
Nutrient Metabolism & Essential Cofactors
B-Vitamin Utilization: Assesses functional conversion efficiency for foundational cofactors such as Vitamin B12, Vitamin B6, and Folate.
Essential Fatty Acid Processing: Maps Omega 3 metabolism and Omega 6 metabolism to help optimize cell membrane fluidity and neuro-protective fatty acid ratios.
Metabolic & Mineral Status: Pinpoints genetic susceptibility to Magnesium deficiency, Glucose metabolism, and lipid-related markers.
Sleep Architecture & Circadian Sensitivity
Restorative Sleep & Resilience: Evaluates genetic drivers of Reported Sleep Quality and biological Sleep Deprivation Susceptibility.
Clinical Utility for Practitioners
Autistic and neurodivergent individuals frequently experience overlapping physiological challenges, including sleep disruptions, environmental and sensory sensitivities, gastrointestinal issues, and altered nutrient processing. Rather than viewing behaviors or sensory needs in isolation, DNA Signature – Spectrum Map empowers practitioners to:
Target Underlying Environmental & Histamine Drivers: Identify sluggish clearance or mast cell reactivity pathways to reduce systemic and neuro-inflammatory burden.
Personalize Neuro-Nutritional Protocols: Optimize precise forms and ratios of B-vitamins, magnesium, and active omega fatty acids based on genetic metabolic capacity.
Protect Sleep Architecture: Design individualized sleep hygiene and diet protocols tailored to specific circadian vulnerabilities.
Our high-complexity laboratory is committed to delivering accurate and reliable results in coordination with these top licensure programs:
Analytes
From a single easy-to-collect buccal swab you will receive a personalized polygenic risk score for the following traits:
ADHD Propensity
Attention Regulation
Methylation Trait
Glucuronidation
Detoxification Capacity
CYPs
PON
Histamine / Mast Cell Activation
Omega 3 Metabolism
Omega 6 Metabolism
Glucose Metabolism
Magnesium Deficiency Risk
Vitamin B12 / B6 / Folate Nutrient Traits
CHD from Lower LDL
Reported Sleep Quality
Caffeine Effect on Sleep
Sleep Deprivation Susceptibility
Sample Reports
The DNA Methylation Profile report aids clinical support for patients by pinpointing SNPs that could potentially impact health and disease risk.
MosaicDX offers patient-friendly sample collection kits that simplify testing. Our kits include visual, step-by-step instructions for test preparation and sample collection, personalized shipping cards, and pediatric collection bags if needed. With MosaicDX, patients can easily collect samples for testing with confidence and accuracy.
No, we do not. A genetic carrier refers to an individual who has inherited a recessive allele that has been shown to be responsible for an autosomal recessive disease or trait. A genetic carrier only has one recessive allele so while they do not show signs or symptoms of the trait or disease, they are able to pass along the recessive gene to their child. Our genetic testing is for screening purposes only to assess risk or predisposition for certain traits associated with health and wellness.
No. We do not use patient samples for further research or testing. We may use your de-identified and anonymized data to help improve our algorithm and reports. Your data will not be sold or shared to or with any 3rd parties/commercial interests.
Yes, we can delete the patient’s raw genetic sequence at any time. Please note that applicable federal and state laws require us to retain your patient report and the subset of your data that was used to generate that report for a specified period of time. We will be happy to delete any and all of your data that we are legally allowed to delete upon request. Please submit your request here.
We implement rigorous selection criteria when choosing which genes or SNPs to include in our panels. The selection and validation criteria are based upon peer-reviewed studies that show a significant association between the SNP variant and trait or condition, the magnitude of the odds ratio (OR) or hazard ratio (HR) to assess risk related to the variant, as well as the population or populations the gene and SNP variant were studied in, the population size, and replication of findings.
A genotype refers to the actual inherited genetic material of an individual that can influence or determine certain characteristics or traits. A phenotype is how the genotype is actually expressed, that is the observable or measurable characteristics or traits of an individual.
SNP is also called a Single Nucleotide Polymorphism. Your DNA consists of 4 main building blocks (nucleotides), Adenine (A), Thymine (T), Guanine (G), and Cytosine (C). In certain locations within your DNA, one person may have an A, whereas another may have a G. This difference in the base pair is often called a variant. This variant is an SNP.
In most situations, you do not have to resubmit a DNA buccal swab sample if you later want to order additional panels. The only time a new DNA buccal swab would need to be resubmitted is if the assay has had significant changes, or the patient previously requested that their DNA sequencing results be deleted.
Patients are sent a DNA Signature Collection Kit containing instructions, 1 cheek swab, a DNA Sample Envelope and a prepaid return envelope and biohazard zip-lock bag. Instructions can also be found on our website on the DNA Signature Profiles web page, along with an easy-to-follow video.
A person’s polygenic risk score is a statistical calculation based on the presence or absence of multiple genomic variants without taking environmental or other factors into account
Different states have regulations that define the scope of practice for practitioners. It is the practitioner’s responsibility to abide by these rules. Check with your state board of health to determine any restrictions related to laboratory testing. Please note, Mosaic Diagnostics does not offer testing in New York.
Once you have opened your account, you have the options of ordering kits to stock in your office or drop-ship kits directly to your patients through your MosaicDX portal.
Watch our short tutorial videos on how to conveniently
