Going Beyond SNPs. Polygenic Risk Scoring for a More Personalized Path Forward.
DNA Signature, a next-generation suite of genomic profiles, looks beyond individual variants, combining polygenic risk scoring with clinical interpretation to translate complex genetics into personalized strategies for better health.
The DNA Signature – Mind & Mood panel Offers insights into genetic factors associated with emotional regulation, cognitive longevity, stress resilience, and sleep architecture; providing insight into the biochemical drivers behind mood and cognitive health. The report translates complex genetic variants into a prioritized, actionable strategy. Empowering practitioners to design personalized neuro-nutritional, lifestyle, and brain-support protocols before functional imbalances progress.
What Patients Might Benefit from DNA Signature -Mind & Mood Testing?
Patients with the following symptoms or conditions may benefit from DNA Signature – Mind & Mood testing
Persistent Mood Imbalances & High Stress Reactivity
Aging Adults & Individuals Focused on Cognitive Health
Patients with Sleep Architecture Disruptions
Methylation & Neuro-Nutritional Bottlenecks
Details
Why Use the DNA Signature – Mind & Mood Profile?
The DNA Signature – Mind & Mood panel provides a comprehensive genomic analysis of neuro-chemical balance, cognitive longevity, stress resilience, and sleep architecture. By evaluating interconnected pathways across central nervous system function, cellular energetics, and neurotransmitter turnover, this panel equips practitioners with an objective blueprint to understand emotional regulation, cognitive trajectory, and restorative rest.
Core Functional Domains Evaluated
Emotional Regulation, Mood & Stress Resilience
Neuro-Behavioral Tendencies: Maps genetic risk profiles and predispositions associated with anxiety, depression, rumination, and OCD behaviors.
GABA & Excitatory Balance: Assesses GAD1 activity to evaluate the conversion of glutamate to GABA, clarifying central nervous system inhibitory tone and anxiety vulnerability.
Stress Response Architecture: Identifies individual Stress Phenotypes and biological Stress Adaptation capacity to explain distinct thresholds for psychological and physiological stress.
Executive Function & Memory: Evaluates genetic markers governing general cognition, memory, attention, and structural white matter integrity.
Neuro-Degenerative Trajectory: Maps baseline risk factors for MCI (Mild Cognitive Impairment), Parkinson’s Disease, and Alzheimer’s Disease (APOE Status) to guide long-term neuro-protective strategies.
Sleep Architecture & Circadian Rest
Sleep Quality & Restorative Depth: Assesses genetic drivers of reported sleep quality and deep sleep quality to evaluate slow-wave sleep efficiency.
Neuro-Emotional Sleep Disruptions: Pinpoints susceptibility to mood-induced sleeplessness, clarifying how stress or emotional rumination disrupts sleep onset and continuity.
Neuro-Metabolic Cofactors & Cellular Energetics
Neurotransmitter Methylation: Evaluates MTHFR Activity to gauge folate conversion, crucial for neurotransmitter synthesis (serotonin, dopamine, norepinephrine) and homocysteinemia management.
Brain Energetics & Antioxidant Defense: Evaluates CoQ10 production pathways driving mitochondrial ATP generation within high-demand neuronal tissue.
Clinical Utility for Practitioners
Neuro-psychiatric symptoms and cognitive changes rarely stem from a single origin. They reflect a dynamic interplay between neurotransmitter kinetics, neuro-inflammation, cellular energy, and sleep. The DNA Signature – Mind & Mood panel bridges genomic architecture and real-world clinical presentation, allowing practitioners to:
Target Neuro-Nutritional Interventions: Precision-dose bioactive B-vitamins, choline, CoQ10, and amino acid precursors based on baseline enzymatic throughput.
Optimize Neuro-Protective Protocols: Implement early, preventative lifestyle and therapeutic measures for individuals carrying genetic markers associated with cognitive decline or white matter changes.
Personalize Mood & Sleep Strategies: Tailor stress-reduction techniques and sleep hygiene protocols according to the patient’s specific stress phenotype and GABAergic pathways.
Our high-complexity laboratory is committed to delivering accurate and reliable results in coordination with these top licensure programs:
Analytes
From a single easy-to-collect buccal swab you will receive a personalized polygenic risk score for the following traits:
Anxiety Propensity
OCD Likelihood
Rumination
Stress Adaptation
Stress Phenotype
General Cognition
Memory
Attention
White Matter
Depression Propensity
MCI (Mild Cognitive Impairment)
Alzheimer’s Disease (APOE)
Parkinson’s Disease
Reported Sleep Quality
Deep Sleep Quality
GAD1 Activity
Mood-Induced Sleeplessness
CoQ10
MTHFR Activity
Choline
Sample Reports
The DNA Methylation Profile report aids clinical support for patients by pinpointing SNPs that could potentially impact health and disease risk.
MosaicDX offers patient-friendly sample collection kits that simplify testing. Our kits include visual, step-by-step instructions for test preparation and sample collection, personalized shipping cards, and pediatric collection bags if needed. With MosaicDX, patients can easily collect samples for testing with confidence and accuracy.
No, we do not. A genetic carrier refers to an individual who has inherited a recessive allele that has been shown to be responsible for an autosomal recessive disease or trait. A genetic carrier only has one recessive allele so while they do not show signs or symptoms of the trait or disease, they are able to pass along the recessive gene to their child. Our genetic testing is for screening purposes only to assess risk or predisposition for certain traits associated with health and wellness.
No. We do not use patient samples for further research or testing. We may use your de-identified and anonymized data to help improve our algorithm and reports. Your data will not be sold or shared to or with any 3rd parties/commercial interests.
Yes, we can delete the patient’s raw genetic sequence at any time. Please note that applicable federal and state laws require us to retain your patient report and the subset of your data that was used to generate that report for a specified period of time. We will be happy to delete any and all of your data that we are legally allowed to delete upon request. Please submit your request here.
We implement rigorous selection criteria when choosing which genes or SNPs to include in our panels. The selection and validation criteria are based upon peer-reviewed studies that show a significant association between the SNP variant and trait or condition, the magnitude of the odds ratio (OR) or hazard ratio (HR) to assess risk related to the variant, as well as the population or populations the gene and SNP variant were studied in, the population size, and replication of findings.
A genotype refers to the actual inherited genetic material of an individual that can influence or determine certain characteristics or traits. A phenotype is how the genotype is actually expressed, that is the observable or measurable characteristics or traits of an individual.
SNP is also called a Single Nucleotide Polymorphism. Your DNA consists of 4 main building blocks (nucleotides), Adenine (A), Thymine (T), Guanine (G), and Cytosine (C). In certain locations within your DNA, one person may have an A, whereas another may have a G. This difference in the base pair is often called a variant. This variant is an SNP.
In most situations, you do not have to resubmit a DNA buccal swab sample if you later want to order additional panels. The only time a new DNA buccal swab would need to be resubmitted is if the assay has had significant changes, or the patient previously requested that their DNA sequencing results be deleted.
Patients are sent a DNA Signature Collection Kit containing instructions, 1 cheek swab, a DNA Sample Envelope and a prepaid return envelope and biohazard zip-lock bag. Instructions can also be found on our website on the DNA Signature Profiles web page, along with an easy-to-follow video.
A person’s polygenic risk score is a statistical calculation based on the presence or absence of multiple genomic variants without taking environmental or other factors into account
Different states have regulations that define the scope of practice for practitioners. It is the practitioner’s responsibility to abide by these rules. Check with your state board of health to determine any restrictions related to laboratory testing. Please note, Mosaic Diagnostics does not offer testing in New York.
Once you have opened your account, you have the options of ordering kits to stock in your office or drop-ship kits directly to your patients through your MosaicDX portal.
Watch our short tutorial videos on how to conveniently
