DNA Methylation Pathway Profile

VDR: (the vitamin D receptor) is a nuclear receptor protein that binds 1,25-dihydroxy vitamin D to activate a signaling molecule that is believed to have important roles in a 3rd of the human genome. Some functions that are known are xenobiotic detoxification.

BHMT: (betaine-homocysteine methylatransferase) is a transferase enzyme that catalyzes the transfer of a methyl group from betaine to homocysteine, which produces methionine. Other enzymatic roles for BHMT is the choline oxidation processes. This enzyme is found in the liver and kidney.

COMT: (catechol-O-methyltransferase) functions in the nerve cells, liver, kidneys, and red blood cells. Its role is to help inactivate 2- and 4-hydroxyestradiols, and catecholamine hormones prior to excretion of bile. COMT is also found in the CNS where its role is the degradation of catecholamine neurotransmitters.

MAO A: (monoamine oxidase type A) its main role is to detoxify biological and xenobiotic amines. This enzyme also degrades neurotransmitters in both the central and peripheral nervous system.

AHCY: (adenosylhomocysteinase) an enzyme that breaks down methionine by converting S-adenosylhomocysteinase into homocysteine. This reaction regulates the methylation of other compounds.

CBS: (cystathionine beta-synthase) this enzyme is responsible for using vitamin B6 to convert serine and homocysteine into cystothionine which will be later converted into cysteine.

MTHFR: (methylenetetrahydrofolate reductase) enzyme responsible for the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate. This reaction allows for the conversion of homocysteine to methionine.

MTR: (methionine synthase) enzyme that catalyzes the re-methylation of homocysteine to methionine using the methyl-B-12 as a cofactor.

MTRR: (methionine synthase reductase) responsible for the regeneration of methyl-B-12.

SHMT: (serine hydroxymethyltransferase) responsible for catalyzing the interconversion of glycine to serine.

SUOX: (sulfite oxidase) mitochondrial enzyme responsible for oxidizing sulfites to sulfates. Sulfites are produced by the transsulfuration cycle or from diet.

Different states have regulations that define the scope of practice for practitioners. It is the practitioner’s responsibility to abide by these rules. Check with your state board of health to determine any restrictions related to laboratory testing. Please note, Mosaic Diagnostics does not offer testing in New York. 

Once you have opened your account, you have the options of ordering kits to stock in your office or drop-ship kits directly to your patients through your MosaicDX portal.   

Watch our short tutorial videos on how to conveniently  

• Order kit for your inventory  
• Drop-ship a kit to your patient  
• Re-order a follow-up test for your patient.    

Already have a kit? Watch this video on how to place an order for your patient using a kit from your inventory.   

Please refer to your test’s specific Test Preparation and Instructions for more information regarding the potential effects of medications, foods, and supplements on this test. 

You make also consult your healthcare provider prior to making any changes to your medications.

Mosaic Diagnostics offers written interpretations within test reports and complimentary consultations with our clinical educators for qualified practitioners. To schedule a consultation, simply sign in to your MosaicDX account and book a consultation online. 

We encourage all patients to discuss results with your practitioner.

Our Resources tab also contains educational materials that you may find useful, we also offer MosaicEDGE workshops for qualified practitioners to better understand the fundamentals of lab testing.