Saliva Hormones Profile

Hormones Comprehensive Panel

Addressing Hormonal Imbalances

Hormones play a vital role in maintaining physical and mental health as imbalances can lead to serious health problems. Both men and women produce hormones like estrogen and testosterone, and balance is key for optimal health.

The old “one-size-fits-all” approach to hormone replacement therapy is outdated, MosaicDX offers comprehensive salivary hormone profiles that measure both sex and stress hormones. Salivary measurement of hormones is non-invasive and convenient to asses unbound biologically active hormone levels. Our profiles help identify hormonal imbalances, allowing for personalized hormone replacement therapies and nutritional interventions.

Turnaround Time: 1-2 weeks

Turnaround times are estimates. Detailed order tracking is available in the MosaicDX Portal.

Hormones Comprehensive Panel

What Patients Might Benefit from Hormones Analysis?

Identifying hormonal imbalances is essential in customizing hormone replacement therapies and other nutritional interventions aimed at relieving the signs and symptoms associated with hormonal imbalances.

  • Anxiety/Depression
  • Brain Fog/ Forgetfulness
  • Breast Tenderness
  • Erectile Dysfunction
  • Fatigue 
  • Hair Loss
  • Hot Flashes
  • Hair Loss
  • Increased Facial/Body Hair
  • Irregular Menstrual Cycles
  • Irritability
  • Low Libido or Stamina
  • Metabolic Syndrome
  • Mood Instability
  • Muscle Mass Loss
  • Muscle Weakness
  • Night Sweats
  • Prostate Enlargement or Cancer
  • Urinary Incontinence
  • Uterine Fibroids
  • Vaginal dryness
  • Weight Gain 


Why Test Hormones?

Each person’s hormone levels are unique, like fingerprints, and require personalized treatment.  Testing major sex hormones like estradiol, estrone, estriol, progesterone, and testosterone along with adrenal hormones like DHEA and cortisol, can provide valuable information about deficiencies, excesses, and daily patterns. A personalized approach to hormone replacement therapy is much more effective than a “one-size-fits-all” approach.

Why Test Using Saliva?

Most hormones in the blood are bound to carrier proteins and not bioavailable to target tissues.  Saliva measures unbound bioavailable hormones, for this reason saliva testing is thought to better relate to specific symptoms of excess or deficiency.  Salivary testing provides a good option for baseline assessment of hormones and to monitor hormone replacement therapies.

Learn More About the Hormones Profile: Explore FAQs


What Hormones Does The MosaicDX Hormones Profile Test?

The major sex hormones to evaluate include estradiol, progesterone, testosterone, estrone, and estriol. Additionally, the main adrenal hormones are DHEA and cortisol. Testing for these hormones can provide valuable information about deficiencies, excesses, and daily patterns, allowing for a personalized treatment approach that is much more effective than the old “shotgun” approach.

Below is an overview of analytes included in the comprehensive and comprehensive plus panels, along with a brief description of each analyte:

Comprehensive Plus
Estradiol (E2)
Estrone (E1)
Estriol (E3)
Progesterone (Pg)
Cortisol AM30
Cortisol Noon
Cortisol Evening
Cortisol Night
EQ (E3/(E1 + E2)) Ratio
Pg/E2 Ratio

Sample Reports

The Hormone test report is a useful resource for practitioners who want to gain valuable insights into bioavailable hormones.

Test Prep and Instructions

MosaicDX offers patient-friendly sample collection kits that simplify testing. Our kits include visual, step-by-step instructions for test preparation and sample collection, personalized shipping cards, and pediatric collection bags if needed. With MosaicDX, patients can easily collect samples for testing with confidence and accuracy.

Patient Resources

Identifying hormonal imbalances is essential in customizing hormone replacement therapies and other nutritional interventions aimed at relieving the signs and symptoms associated with hormonal imbalances.

Take our symptom checker to help identify if you are experiencing hormonal imbalances:

Numbers in the chart represent the severity of each symptom:

0 – None  |  1 – Mild  |  2 – Moderate  |  3 – Severe

Add up the total number for the patient’s symptoms. The higher the total, the more likely the patient has a corresponding hormonal condition. This should help guide you to the most appropriate test.


Symptoms and diseases associated with hormonal imbalances may include:

Men or Women Experiencing:
Women Experiencing:
Men Experiencing:
Weight gain
Hot flashes
Decreased libido
High blood sugar
Night sweats
Erectile dysfunction
Elevated lipids (cholesterol and/or triglycerides)
Breast tenderness
Loss of stamina
Decrease in mental sharpness
Reduced muscle size
Irregular menstrual cycles
Increased moodiness
Decreased stamina
Vaginal dryness
Metabolic syndrome
Urinary incontinence
Prostate enlargement or cancer
Chronic disease
Uterine fibroids
Hot flashes
Increased facial / body hair

Frequently Asked Questions

The ordering process for MosaicDX tests starts with your healthcare practitioner assessing your symptoms and recommending the most appropriate test.

Once a test has been recommended, collection kits can be conveniently ordered and delivered straight to your doorstep. If you already have a collection kit, you can register your test and begin the process at your convenience.

It is important to carefully follow the collection instructions and include all required information about yourself and your specimens when registering your test. When your specimens are collected, you can use the prepaid shipping materials provided in your kit to ship them to MosaicDX. Your results will be accessible online via the MosaicDX portal. We recommend scheduling an appointment with your healthcare practitioner to discuss your results and develop a plan for your healthcare

If you are located outside of the U.S., our customer service team can assist you in finding a distributor in your country. In countries where a distributor is not required, you can place an order through our international patient ordering site. Please note that all international shipping costs must be paid prior to shipping the kit.  

Stress can manifest in various forms, including mental, physiological, and environmental stressors, and can trigger a physiological response in the body. The body’s ability to cope with daily stress is influenced by various factors that can tax its systems, such as allergies, environmental pollutants, infections, sleep deprivation, and mental illness. When confronted with physical or emotional stress, the adrenal glands release cortisol and DHEA, which can be beneficial in handling immediate challenges. However, prolonged exposure to a constant “fight or flight” response can accelerate aging and lead to health problems. In today’s fast-paced world, people often have little time to allow their bodies to recover from stress, which can result in chronic stress. Chronic stress can have a negative impact on cardiovascular health, reproduction, mental health, anxiety, immune function, blood sugar stability, and increase the risk of cancer.

Testosterone is the main sex hormone in males and is secreted in intermittent bursts throughout the day. As an anabolic hormone, it plays a vital role in both male and female physiology. Adequate levels of testosterone are crucial for maintaining healthy bones, robust muscle strength, endurance, sexual desire and performance, cardiovascular health, and mental acuity.

As females transition into adulthood, their bodies undergo hormonal changes that initiate the onset of menstruation. The menstrual cycle consists of two distinct phases – the first phase, which occurs before ovulation, is characterized by a dominance of estrogen, while the second phase, which occurs after ovulation, is characterized by a dominance of progesterone. These monthly fluctuations between estrogen and progesterone are essential for maintaining a woman’s well-being. In men, a correlation has been observed between elevated levels of estrogen and decreased levels of testosterone, which may increase the risk of prostate issues.

Different states have regulations that define the scope of practice for practitioners. It is the practitioner’s responsibility to abide by these rules. Check with your state board of health to determine any restrictions related to laboratory testing. Please note, Mosaic Diagnostics does not offer testing in New York. 

Once you have opened your account, you have the options of ordering kits to stock in your office or drop-ship kits directly to your patients through your MosaicDX portal.   

Watch our short tutorial videos on how to conveniently  

Already have a kit? Watch this video on how to place an order for your patient using a kit from your inventory.   

Please refer to your test’s specific Test Preparation and Instructions for more information regarding the potential effects of medications, foods, and supplements on this test. 

You make also consult your healthcare provider prior to making any changes to your medications.

Visit the payment information page for an overview of payment options and procedures along with insurance coverage overview.

NOTE: Insurance coverage for testing is based on several factors such as the type of procedure, diagnosis, and insurance policy guidelines. Patients are encouraged to contact their insurance company to check for coverage and to provide the procedure codes (CPT codes) and diagnostic codes (ICD-10 codes). The CPT codes can be found on the billing information page, while ICD-10 codes are provided by the practitioner.

Mosaic Diagnostics offers written interpretations within test reports and complimentary consultations with our clinical educators for qualified practitioners. To schedule a consultation, simply sign in to your MosaicDX account and book a consultation online. 

We encourage all patients to discuss results with your practitioner.

Our Resources tab also contains educational materials that you may find useful, we also offer MosaicEDGE workshops for qualified practitioners to better understand the fundamentals of lab testing.

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Clinical References