Lyme + Co-Infections

The next generation of Lyme + Co-Infection Diagnostics—designed to detect at every stage

Testing for Lyme disease and co-infections, in combination, provides a more comprehensive assessment of tick and vector-borne exposures. MosaicDX’s Lyme + Co-infection combination panels streamline the identification process, reduce costs, and offer unparalleled visibility, ensuring prompt and effective treatment.

We offer nine (9) individual tests and combinations of the most common Lyme and co-infections in North America, with options designed to meet every practitioner’s need.

Lyme Co-Infections Logo
Lyme Borrelia Direct Detect
Bartonella IgG Detect – IFA
Tickborne BBB Direct Detect
(1 or 3 day)
Methodology
Nanotrap®
Direct
Immuno- fluorescence (IFA)
Indirect
Digital PCR (dPCR)
Direct
Sample Type
UrineUrine
SerumSerum (yellow top)
BloodBlood (lavender top)
INDIVIDUAL PROFILES
COMBINATION PROFILES
Blood, Serum, Urine
Practitioners:
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For Non-Practitioners:

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View Full Analytes List
Sample Reports | Test Prep and Instructions

Patients presenting with flu-like symptoms, with or without Erythema migrans (EM) rash, and have lived or traveled to an area where Lyme disease is endemic.

Patients with chronic illness not improving, and past/present exposure to ticks, even with past treatment of Lyme, or Post-Treatment Lyme Disease Syndrome (PTLDS) or co-infections.

Patients with chronic illness not improving, and past/present exposure to ticks, fleas, lice, spiders or companion animals.

  • Abdominal pain
  • Anorexia
  • Anxiety and depression
  • Arthritis
  • Bladder and pelvic pain
  • Body aches
  • Cardiovascular issues (endocarditis)
  • Carditis or heart block
  • Changes in bowel habits
  • Depression
  • Eye and vision problems (such as floaters, light sensitivity, and blurry vision)
  • Facial pain and tooth issues
  • Fatigue / chronic fatigue / profound fatigue
  • Fever
  • Fibromyalgia
  • Flu-like illness
  • Headaches
  • Joint pain
  • Localized or disseminated EM
  • Malaise
  • Muscle pain / soreness
  • Muscle/limb impairment or paralysis
  • Neurological manifestations
  • Neurological symptoms such as facial paralysis, blindness
  • Psychiatric symptoms (rage)
  • Rash “striae”
  • Seizures
  • Sleeplessness
  • Swollen lymph nodes in the head, neck, arms, and along the shins

Details

MosaicDX offers nine (9) individual tests and combinations of the most common Lyme and co-infections in North America, with options designed to meet every practitioner’s need.

Combinations and Complementary Test Recommendations

Ticks, fleas and other vectors can transmit multiple infections. To help prioritize treatment, providers should consider additional Lyme and Co-infection tests to identify which pathogens are currently present.

View View Lyme + Co-Infection Test Comparison Chart



Bartonella Indirect IFA – Practitioner Brochure


Tickborne BBB Direct Detect dPCR – Practitioner Brochure


Lyme Borrelia Direct Detect Nanotrap – Practitioner Brochure

Analytes

Analytes in each profile:

Lyme Borrelia Direct Detect – Nanotrap®
Outer Surface Protein Antigen A (OspA)

Tickborne BBB Direct Detect – dPCR
Babesia spp. 1 or 3 days
Bartonella spp. 1 or 3 days
Borrelia spp. 1 or 3 days
Bartonella spp. Culture dPCR 3 days

Bartonella IgG Detect – IFA
Bartonella henselae
Bartonella koehlerae
Bartonella quintana
Bartonella vinsonii berkhoffii

Sample Reports

Lyme + Bartonella – Sample Test Report (Sample Report)
Lyme + Co-infections Comprehensive 1 day – Sample Test Report (Sample Report)
Lyme + Co-infections Comprehensive 3 day – Sample Test Report (Sample Report)
Lyme Borrelia Direct Detect – Nanotrap® – Sample Test Report (Sample Report)
Bartonella IgG Detect – IFA – Sample Test Report (Sample Report)
Tickborne BBB Direct Detect 1 day – dPCR – Sample Test Report (Sample Report)
Tickborne BBB Direct Detect 3 day – dPCR – Sample Test Report (Sample Report)
Tickborne BBB Plus 1 day – Sample Test Report (Sample Report)
Tickborne BBB Plus 3 day – Sample Test Report (Sample Report)

Test Prep and Instructions

Lyme + Co-infections Collection Instructions

Explore our Lyme + Co-Infections Resources

View All Resources
Webinars

Untangling the Web: A Functional Medicine Approach to Lyme & Mold

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Collection Instructions
Glyphosate Test – Water | Collection Kit Instructions

Lyme + Co-infections Collection Instructions

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Blogs
Lyme, Mold and Mycotoxins: Strategies for Navigating Complex Illness

Lyme, Mold and Mycotoxins: Strategies for Navigating Complex Illness

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Blogs
The Five Key Tests for Environmental Toxicity Assessment

Lyme, Mold, Mycotoxins & Testing Answers with Jasmyne Brown, ND, Darin Ingels, ND & More!

Read More

Related Tests

Ticks, fleas and other vectors can transmit multiple infections—not just Bartonella. To help prioritize treatment, providers should consider additional Lyme and Co-infection tests to identify which pathogens are currently present.

Search All Tests
Lyme + Co-infections
Bartonella IgG Detect – IFA:

Exposure to infected fleas, tickes, spiders, and lice, or companion and wild animals can cause B…

View Test
Lyme + Co-infections
Lyme Borrelia Direct Detect – Nanotrap®:

Discover the Power of MosaicDX’s Lyme Borrelia Direct Detect profile that provides more se…

View Test
Lyme + Co-infections
Tickborne BBB Direct Detect 1 day – dPCR: The most sensitive test methodology available for direct detection of Bartonella, Babesia, and Borr…
View Test

Frequently Asked Questions

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Clinical References

  1. Maggi, R.G., Calchi, A.C., Moore, C.O. et al. Human Babesia odocoilei and Bartonella spp. co-infections in the Americas. Parasites Vectors 17, 302 (2024). https://doi.org/10.1186/s13071-024-06385-4. 
  1. Hildebrand, J., Buńkowska-Gawlik, K. & Perec-Matysiak, A. Co-occurrence of Babesia microti, Bartonella spp., Borrelia burgdorferi s.l. and Anaplasma phagocytophilum in rodents from Lower Silesia, Poland. Parasites Vectors 7 (Suppl 1), O4 (2014). https://doi.org/10.1186/1756-3305-7-S1-O4. 
  1. Breitschwardt E. The Evolving Biomedical Importance of Bartonella Species Infections. Pathogens. Special Issue. Bacterial Pathogens. ISSN 2076-0817. Accessed May 2025. 
  1. Infectious Disease Society of America 2020 Guideline on Diagnosis and Management of Babesiosis. Clinical Infectious Diseases, Volume 72, Issue 2, 15 January 2021, Pages e49-e64, https://doi.org/10.1093/cid/ciaa1216. 

  1. Spach, David. UpToDate. Biology of Bartonella Species. Accessed 05/2025. 
  1. Breitschwerdt E. Bartonellosis: One Health Perspectives for an Emerging Infectious Disease. ILAR Journal, Volume 55, Issue 1, 2014, Pages 46–58, https://doi.org/10.1093/ilar/ilu015 
  1. Bush J, Robveille C, Maggi R, et al. Bush, J.C., Robveille, C., Maggi, R.G. et al. Neurobartonelloses: emerging from obscurity! Parasites Vectors 17, 416 (2024). https://doi.org/10.1186/s13071-024-06491-3 
  1. Maggi, R.G., et al. (2005). Bartonella spp. bacteremia in patients with neurological and neurocognitive dysfunction. Journal of Clinical Microbiology, 43(9), 4818-4822. 
  1. Breitschwerdt, E.B., et al. (2008). Bartonella spp. bacteremia and rheumatic symptoms in patients from Lyme disease-endemic region. Emerging Infectious Diseases, 14(5), 653-660. 
  1. Breitschwerdt E, Atkins C, Brown T, et al. Bartonella vinsonii subsp. Berkhoffi and Related Members of the Alpha Subdivision of the Proteobacteria in Dogs with Cardiac Arrhythmias, Endocarditis, or Myocarditis. Journal of Clinical Microbiology. Nov 1999, Vol 37 No 11: 3618-26. 
  1. Cheslock M, and Embers M. Human Bartonellosis: An Underappreciated Public Health Problem? Tropical Medicine and Infectious Disease Review April 2019. 
  1. Boaz A, Graidy M, Efrat G, et al. Bartonella Koehlerae, a New Cat-Associated Agent of Culture-Negative Human Endocarditis. Journal of Clinical Microbiology, Aug. 2004, v42 No 8: 3462–3468. 
  1. Project Lyme. What is Bartonella. Accessed May 2025. 
  1. Centers for Disease Control and Prevention. About Bartonella Henselae. Accessed May 2025. 
  1. Galaxy Diagnostics. What is Bartonellosis. Accessed May 2025. 

  1. Shapiro, Eugene. Borrelia burgdorferi (Lyme Disease). Pediatr Rev (2014) 35 (12): 500–509. https://doi.org/10.1542/pir.35-12-500 
  1. Pfeifle A, Duvall, R, Tamming L, et al. Borrelia burgdorferi Strain-Specific Differences in Mouse Infectivity and Pathology. Pathogens 2025, 14(4), 352; https://doi.org/10.3390/pathogens14040352. 
  1. Centers for Disease Control and Prevention. Comparison of Lyme Disease in the United States and Europe. Emerging Infectious Diseases. Vol. 27, Number 8—August 2021 
  1. Wilcox J, Mankoff S, Stricker J. Severity of chronic Lyme disease compared to other chronic conditions: a quality of life survey. PeerJ. 2014; 2:e322. PMID: 24749006 PMCID: PMC3976119. 
  1. Sellati, T, and Barberio D. Mechanisms of Dysregulated Antibody Response in Lyme Disease. Front Cell Infect Microbiol. 2020 Oct 7;10:567252. doi: 10.3389/fcimb.2020.567252. 
  1. Magni R, Espina B, Shah K, et al. Application of Nanotrap technology for high sensitivity measurement of urinary outer surface protein A carboxyl-terminus domain in early stage Lyme borreliosis. J Transl Med. 2015 Nov 4;13:346. doi: 10.1186/s12967-015-0701-z. 
    Aucott, J, Rebman A, et al. Post-treatment Lyme disease syndrome symptomatology and the impact on life functioning: is there something here? Qual Life Res. 2012 Feb 1;22(1):75–84. doi: 10.1007/s11136-012-0126-6
  2. International Lyme and Associated Diseases Society (ILADS). Lyme Disease Basics For Providers. https://www.ilads.org/research-literature/lyme-disease-basics-for-providers/. Accessed May 2025.
  3. Centers for Disease Control and Prevention (CDC). How Lyme Disease Spreads. https://www.cdc.gov/lyme/causes/index.html. Accessed May 2025.
  4. Melski JW. Lyme borreliosis. Semin Cutan Med Surg. 2000 Mar;19(1):10-8. doi: 10.1053/sd.2000.7373. PMID: 10834603.
  5. Kurokawa, C., Lynn, G.E., Pedra, J.H.F. et al. Interactions between Borrelia burgdorferi and ticks. Nat Rev Microbiol 18, 587–600 (2020). https://doi.org/10.1038/s41579-020-0400-5.
  6. Infectious Disease Society of America (IDSA). AAN/ACR/IDSA 2020 Guidelines for the Prevention, Diagnosis and Treatment of Lyme Disease. Clinical Infectious Diseases, Volume 72, Issue 1, 1 January 2021, Pages e1-e48, https://doi.org/10.1093/cid/ciaa1215
  7. Cameron D, Johnson L, Maloney E. International Lyme and Associated Diseases Society (ILADS). Evidence Assessments and Guideline Recommendations in Lyme Disease: The Clinical Management of Known Tick Bites, Erythema Migrans Rashes and Persistent Disease. https://www.ilads.org/patient-care/ilads-treatment-guidelines/. Accessed May 2025.