Streptococcus Antibodies Profile

Streptococcus Antibodies Profile

Screen for ADB and ASO

This profile screens for the two most common antibodies against streptococcus, DNase antibodies in serum (ADB); antistreptolysin O titer (ASO). These antibodies may cross-react with brain tissue causing abnormal behaviors. Both of these tests are performed to identify a previous infection of group A beta-hemolytic Streptococcus. These infections cause rheumatic fever or a kidney disease called glomerulonephritis, poststreptococcal versions of these diseases, as well as scarlet fever.

Recently, high titers of these antibodies have been associated with PANDAS (Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal Infections) and with Autism Spectrum Disorders, Tourette syndrome, tic disorder, Parkinson’s disease, and OCD.

Turnaround Time: 1-2 weeks

Turnaround times are estimates. Detailed order tracking is available in the MosaicDX Portal.


What Are Pandas?

Group A β-hemolytic streptococci (GABHS) infections can cause several immune-mediated diseases. Rheumatic fever (RF), primarily a childhood disease, is a classic example of a complication resulting from a GABHS infection. RF is an inflammatory disease of the heart, joints, and central nervous system that occurs two to three weeks after a GABHS infection. Antibodies that formed against the GABHS organisms cross-react with normal human tissues, causing heart valve damage, inflamed joints and neurological disorders. Sydenham’s Chorea, characterized by uncontrolled movements of the face, hands, and feet is a common neurological disorder seen in rheumatic fever caused by the cross reactivity of antibodies with brain tissue. These movements are strikingly similar to motor tics, and many patients also display phonic tics, OCD, and ADHD. This observation, along with reports of sudden-onset tics and psychiatric disorders following an outbreak of GABHS in Rhode Island in the early 1990’s, lead to a new diagnostic subcategory of Tourette’s syndrome called PANDAs. Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections, or PANDAs, display episodic symptoms of Tourette’s syndrome following streptococcal infections. There is often a recovery period as the GABHS antibodies reduce to normal. Helping the brain recover with nutrients may reduce vulnerability to further damage by the strep antibodies.

Learn More About the Streptococcus Antibodies Profile: Explore FAQs


This test will screen for:

  • DNase antibodies in serum (ADB)
  • Antistreptolysin O titer (ASO)

Sample Reports

The Streptococcus Antibodies Profile report aids clinical support for patients screening for the two most common antibodies against streptococcus.

Test Prep and Instructions

MosaicDX offers patient-friendly sample collection kits that simplify testing. Our kits include visual, step-by-step instructions for test preparation and sample collection, personalized shipping cards, and pediatric collection bags if needed. With MosaicDX, patients can easily collect samples for testing with confidence and accuracy.

Frequently Asked Questions

The ordering process for MosaicDX tests starts with your healthcare practitioner assessing your symptoms and recommending the most appropriate test.

Once a test has been recommended, collection kits can be conveniently ordered and delivered straight to your doorstep. If you already have a collection kit, you can register your test and begin the process at your convenience.

It is important to carefully follow the collection instructions and include all required information about yourself and your specimens when registering your test. When your specimens are collected, you can use the prepaid shipping materials provided in your kit to ship them to MosaicDX. Your results will be accessible online via the MosaicDX portal. We recommend scheduling an appointment with your healthcare practitioner to discuss your results and develop a plan for your healthcare

If you are located outside of the U.S., our customer service team can assist you in finding a distributor in your country. In countries where a distributor is not required, you can place an order through our international patient ordering site. Please note that all international shipping costs must be paid prior to shipping the kit.  

Different states have regulations that define the scope of practice for practitioners. It is the practitioner’s responsibility to abide by these rules. Check with your state board of health to determine any restrictions related to laboratory testing. Please note, Mosaic Diagnostics does not offer testing in New York. 

Once you have opened your account, you have the options of ordering kits to stock in your office or drop-ship kits directly to your patients through your MosaicDX portal.   

Watch our short tutorial videos on how to conveniently  

Already have a kit? Watch this video on how to place an order for your patient using a kit from your inventory.   

Please refer to your test’s specific Test Preparation and Instructions for more information regarding the potential effects of medications, foods, and supplements on this test. 

You make also consult your healthcare provider prior to making any changes to your medications.

Visit the payment information page for an overview of payment options and procedures along with insurance coverage overview.

NOTE: Insurance coverage for testing is based on several factors such as the type of procedure, diagnosis, and insurance policy guidelines. Patients are encouraged to contact their insurance company to check for coverage and to provide the procedure codes (CPT codes) and diagnostic codes (ICD-10 codes). The CPT codes can be found on the billing information page, while ICD-10 codes are provided by the practitioner.

Mosaic Diagnostics offers written interpretations within test reports and complimentary consultations with our clinical educators for qualified practitioners. To schedule a consultation, simply sign in to your MosaicDX account and book a consultation online. 

We encourage all patients to discuss results with your practitioner.

Our Resources tab also contains educational materials that you may find useful, we also offer MosaicEDGE workshops for qualified practitioners to better understand the fundamentals of lab testing.

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