What Are Pandas?
Group A β-hemolytic streptococci (GABHS) infections can cause several immune-mediated diseases. Rheumatic fever (RF), primarily a childhood disease, is a classic example of a complication resulting from a GABHS infection. RF is an inflammatory disease of the heart, joints, and central nervous system that occurs two to three weeks after a GABHS infection. Antibodies that formed against the GABHS organisms cross-react with normal human tissues, causing heart valve damage, inflamed joints and neurological disorders. Sydenham’s Chorea, characterized by uncontrolled movements of the face, hands, and feet is a common neurological disorder seen in rheumatic fever caused by the cross reactivity of antibodies with brain tissue. These movements are strikingly similar to motor tics, and many patients also display phonic tics, OCD, and ADHD. This observation, along with reports of sudden-onset tics and psychiatric disorders following an outbreak of GABHS in Rhode Island in the early 1990’s, lead to a new diagnostic subcategory of Tourette’s syndrome called PANDAs. Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections, or PANDAs, display episodic symptoms of Tourette’s syndrome following streptococcal infections. There is often a recovery period as the GABHS antibodies reduce to normal. Helping the brain recover with nutrients may reduce vulnerability to further damage by the strep antibodies.
Learn More About the Streptococcus Antibodies Profile: Explore FAQs
This test will screen for:
- DNase antibodies in serum (ADB)
- Antistreptolysin O titer (ASO)
The Streptococcus Antibodies Profile report aids clinical support for patients screening for the two most common antibodies against streptococcus.
Test Prep and Instructions
MosaicDX offers patient-friendly sample collection kits that simplify testing. Our kits include visual, step-by-step instructions for test preparation and sample collection, personalized shipping cards, and pediatric collection bags if needed. With MosaicDX, patients can easily collect samples for testing with confidence and accuracy.