Calcium + Magnesium Profile

Calcium + Magnesium Profile

Major Factors in Bone and Muscle Health

The Calcium + Magnesium Profile is an assessment of urinary levels of calcium and magnesium. Since magnesium works closely with calcium it is important to have an appropriate ratio of both of these critical minerals in order for them to be effective.

Turnaround Time: 1-2 weeks

Turnaround times are estimates. Detailed order tracking is available in the MosaicDX Portal.

Calcium + Magnesium Profile
* Available in English, Spanish, Italian


Why Assess Calcium Levels?

Calcium plays a critical role in the body as it is tightly regulated and necessary for nerve function. Additionally, it is a structural element in bones and teeth, with 99% of the body’s calcium being stored in the bones. A drop of about 30% in plasma calcium levels can result in tetany, a potentially fatal condition that causes overstimulation of the nerves in both the central and peripheral nervous systems, leading to skeletal muscle contractions.

Plasma calcium concentration is a constant laboratory value, with a normal range of 9-11 mg per dL, regardless of the diet. An average adult takes in about 750 mg of calcium per day and secretes about 625 mg of calcium in the intestinal juices. If all the ingested calcium is absorbed, there would be a net absorption of 125 mg per day. On average, an individual excretes about 125 mg of calcium per day in their urine, resulting in a zero net calcium balance except when bone is being deposited. When bone is being deposited, the regulation of urinary calcium excretion is a crucial factor in allowing for bone growth. Urine calcium is the best indicator of adequate dietary calcium since it is under tight hormonal control.

The most common causes of low urine calcium levels are an insufficient dietary intake of calcium and/or a high oxalate diet. Calcium deficiency can also occur due to hypoparathyroidism, pseudohypoparathyroidism, vitamin D deficiency, nephrosis, nephritis, bone cancer, hypothyroidism, celiac disease, and malabsorption disorders.

Why Assess Magnesium Levels?

Like calcium, magnesium is an essential element, with 66% of the body’s magnesium stored in the bones. It is a cofactor in many enzymatic reactions, especially those requiring vitamin B6. When magnesium levels are extremely low, it can cause muscle tetany, similar to what happens with severely low calcium levels. A low magnesium diet may also increase the incidence of oxalate crystal formation in the tissues and kidney stones. Early signs of magnesium deficiency include loss of appetite, nausea, vomiting, migraine headaches, fatigue, and weakness.

High urine magnesium levels are most commonly caused by a high magnesium diet. Other less common causes include insulin resistance, alcoholism, diuretic use, primary aldosteronism, hyperthyroidism, vitamin D excess, gentamicin toxicity, and cis-platinum toxicity. Marked magnesium excess can cause symptoms such as diarrhea, hypotension, nausea, vomiting, facial flushing, retention of urine, ileus, depression, and lethargy.

Learn More About the Calcium + Magnesium Profile: Explore FAQs


An appropriate ratio of both these critical minerals is required in order for them to be effective.

  • Calcium
  • Magnesium

Sample Reports

The Calcium and Magnesium Test report can help to determine if levels are adequate for optimal health.

Test Prep and Instructions

MosaicDX offers patient-friendly sample collection kits that simplify testing. Our kits include visual, step-by-step instructions for test preparation and sample collection, personalized shipping cards, and pediatric collection bags if needed. With MosaicDX, patients can easily collect samples for testing with confidence and accuracy.

Frequently Asked Questions

The ordering process for MosaicDX tests starts with your healthcare practitioner assessing your symptoms and recommending the most appropriate test.

Once a test has been recommended, collection kits can be conveniently ordered and delivered straight to your doorstep. If you already have a collection kit, you can register your test and begin the process at your convenience.

It is important to carefully follow the collection instructions and include all required information about yourself and your specimens when registering your test. When your specimens are collected, you can use the prepaid shipping materials provided in your kit to ship them to MosaicDX. Your results will be accessible online via the MosaicDX portal. We recommend scheduling an appointment with your healthcare practitioner to discuss your results and develop a plan for your healthcare

If you are located outside of the U.S., our customer service team can assist you in finding a distributor in your country. In countries where a distributor is not required, you can place an order through our international patient ordering site. Please note that all international shipping costs must be paid prior to shipping the kit.  

Different states have regulations that define the scope of practice for practitioners. It is the practitioner’s responsibility to abide by these rules. Check with your state board of health to determine any restrictions related to laboratory testing. Please note, Mosaic Diagnostics does not offer testing in New York. 

Once you have opened your account, you have the options of ordering kits to stock in your office or drop-ship kits directly to your patients through your MosaicDX portal.   

Watch our short tutorial videos on how to conveniently  

Already have a kit? Watch this video on how to place an order for your patient using a kit from your inventory.   

To ensure optimal results, it is recommended to ship urine specimens to the laboratory immediately after collection as they start degrading in quality soon after. In case immediate shipping is not possible, here are some guidelines for specimen stability: Urine samples can be stored in the refrigerator for up to 5 days, and for extended periods in the freezer. This applies to all urine tests performed at MosaicDX, except for the Kryptopyrrole test, for which urine must be frozen immediately and received within 24 hours of collection for accurate results. 

Please refer to your test’s specific Test Preparation and Instructions for more information regarding the potential effects of medications, foods, and supplements on this test. 

You make also consult your healthcare provider prior to making any changes to your medications.

Visit the payment information page for an overview of payment options and procedures along with insurance coverage overview.

NOTE: Insurance coverage for testing is based on several factors such as the type of procedure, diagnosis, and insurance policy guidelines. Patients are encouraged to contact their insurance company to check for coverage and to provide the procedure codes (CPT codes) and diagnostic codes (ICD-10 codes). The CPT codes can be found on the billing information page, while ICD-10 codes are provided by the practitioner.

Mosaic Diagnostics offers written interpretations within test reports and complimentary consultations with our clinical educators for qualified practitioners. To schedule a consultation, simply sign in to your MosaicDX account and book a consultation online. 

We encourage all patients to discuss results with your practitioner.

Our Resources tab also contains educational materials that you may find useful, we also offer MosaicEDGE workshops for qualified practitioners to better understand the fundamentals of lab testing.

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Clinical References