How the Body Metabolizes Environmental Toxicants: Metabolite Chart

Environmental toxicants, as detected by our TOXDetect Profile, play a significant role in understanding our exposures. By recognizing how they are metabolized, even more insights can be gleaned about timing of exposure, the ability to eliminate them, and what additional influences they may be having on the system. It is essential to note that many of these toxicants are lipophilic, meaning they have an affinity for fat, allowing them to be more readily absorbed, particularly from dermal exposures.¹ Being lipophilic means they also have a higher potential to be stored in lipids (e.g. cell membranes, adipose tissue), and need to go through biotransformation (i.e. Phase I and II of detoxification) to be eliminated.¹ The chart below illustrates the parent compound, the metabolite of the parent compound, half-lives, and metabolic processes of these toxicants, including common classes such as phthalates, volatile organic compounds (VOCs), and pesticides. Phthalates, often found in plastics, VOCs from industrial emissions, and pesticides used in agriculture are prominent examples of environmental contaminants that the body must process and eliminate.

The liver is crucial in managing these lipophilic substances, as it transforms them through a series of detoxification phases to make them more hydrophilic (water-soluble) and easier to secrete. This process involves three key phases: Phase I, Phase II, and Phase III, each playing a unique role in detoxification. For a comprehensive understanding of these phases and nutrients that support these intrinsic reactions, you can refer to The Liver: It’s Important Role in Detoxification and The Liver: Supportive Nutrients in Detoxification. The first article details the phases and specific reactions involved in liver detoxification, while the second explores the nutrients and plant derivatives that enhance these processes and promote liver health.

Summary 

TOXDetect Profile offers a comprehensive approach to evaluating environmental toxicant exposures, complemented by a thorough environmental exposure history intake. This combination equips practitioners with insights needed to understand how toxicants influence patient health and to implement evidence-based avoidance strategies, address health impacts, and tailor personalized therapeutic interventions. Our goal is to empower you to proactively mitigate the effects of environmental toxicants, fostering long-term health and well-being for both you and your patients.  

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