The Toxicity of Trichothecenes – Insights Into This Unique Group of Mycotoxins


Kurt Woeller, DO, FMAPS


Mycotoxins are toxic compounds produced by many different types of molds. A certain group of mycotoxins called trichothecenes are a large group of chemically related compounds produced by such molds as Fusarium and Stachybotrys. Trichothecenes have some unique toxicity effects, including on cellular production of proteins, DNA synthesis, and more. This lecture will explore various mycotoxins within the trichothecene family and some of their related cytotoxicities.

Q: Is it true that ammonia is an electron donor that degrades the integrity of the epoxide ring?

A: Amines are derived from ammonia and amines can act as nucleophile which attack the epoxide ring – 


Q: Dr. Ritchie Shoemaker has deemphasized mycotoxins as a cause of CIRS, saying they are less than 7% of gene activations. He has substituted endotoxins and actinomycetes. Many of his practitioners are saying this doesn’t matter, because the structure of these toxins is “all the same.” This has caused them to discount Stachybotrys. Can you address Dr. Shoemakers altered position on toxic mold?

A: I have not dived deeply in Dr. Shoemaker’s claims. From my research, various mycotoxins can be significantly problematic for various reasons through their biological functions. A chemical may have a similar chemical structure on paper, but even subtle differences based on changing functional groups, positions of these groups on the molecule which can alter the chemicals orbital configurations, etc. are sometimes enough to change its cellular reactivity. 


Q: Do the same things occur in the body when these are inhaled vs being absorbed in the GI or skin? 

A: Yes, from my research and understanding. Now, there certainly could be some differences in specific cellular responses within the gut versus the skin, but when these toxins find their way into the lymphatic system, and eventually the bloodstream their distribution throughout the body to other organ systems should be the same.


Q: Which probiotics are low in histamine? 

A: Here is the link from presentation. This article is a good place to start your research.


Q: I am curious of your thoughts on the carnivore diet for patients?

A: I have not looked into this.


Q: What does PQQ mean?

A: Pyrroloquinoline Quinone – stimulates mitogenesis

The material contained within this article and webinar is not intended to replace the services and/or medical advice of a licensed healthcare practitioner, nor is it meant to encourage diagnosis and treatment of disease. It is for educational purposes only. Any application of suggestions set forth in the portions of this article is at the reader’s discretion and sole risk. Implementation or experimentation with any supplements, herbs, dietary changes, medications, and/or lifestyle changes, etc., is done so at your sole risk and responsibility.

Kurt Woeller DO

About the Author

Kurt Woeller, DO, FMAPS

Kurt N. Woeller, DO, FMAPS, is a Doctor of Osteopathic Medicine, integrative and functional medicine physician, and biomedical Autism Treatment Specialist in clinical practice for over 25 years.

Dr. Woeller is the education director and main course developer for his Integrative Medicine Academy (https://integrativemedicineacademy.com), an online academy for health professionals. He is also the Organic Acids Test (OAT) seminar creator and presenter for Mosaic Diagnostics Laboratory (formally Great Plains Laboratory’s GPL Academy) Mosaic EDGE seminars and has been involved in monthly educational webinars for GPL/Mosaic Diagnostics, and other organizations for over a decade.

His private practice, Sunrise Functional Medicine (https://mysunrisecenter.com), focuses on specialized diagnostic testing and treatments for individuals with complex medical conditions like autism, autoimmune, gastrointestinal, certain neurological disorders, and other chronic health conditions. Dr. Woeller is a Fellow of the Medical Academy of Pediatric Special Needs (MAPS).

He has served as a clinical consultant for various laboratory companies, i.e., Great Plains Laboratory, BioHealth Laboratory, providing health practitioner education regarding functional and integrative medicine.

You can follow Dr. Woeller for ongoing education articles and videos through his Substack at https://drwoeller.substack.com/ and his YouTube channel for Integrative Medicine Academyhttps://www.youtube.com/@integrativemedicineacademy. Finally, listen to Dr. Woeller’s latest health professional interviews through his Functional Medicine Doc Talk Podcast – https://functionalmedicinedoctalk.com.