The Biological Role of Exosomes


Kurt Woeller, DO, FMAPS


Multivesicular bodies (MVBs) are components of the endocytic pathway which are critical for cellular signaling pathways, bundling of molecules for specialized purposes, receptor recycling, etc. With fusion of MVBs to the plasma membrane the release of exosomes occurs which influence the cell-to-cell communication system. Exosomes can be transported through the body and play a role in normal physiology, as well as disease. For example, exosomes can facilitate cell-to-cell transport of disease-related proteins such as prions and beta-amyloid proteins. This webinar will explore some of the fascinating details of exosomes and their link to various diseases.

Q: Is there any way to put targeted molecules into exosomes to target diseases?

A: This is ongoing research and appears to be the goal for many things such as cancer therapy.


Q: Have you heard of plasmalogens and Dr. Dayan Goodenowe’s work? If so, what do you think about his test and supplements?

A: I have heard of plasmalogens, but not this doctor. Will do some research into this.


Q: Does that mean plant-based diets are not good?

A: A plant-based diet or mostly a plant-based diet is essential for health. It is plant-based foods that appear to have a health-promoting effect on the digestive system microbiome. It appears that with a healthy and diverse microbiome we are likely producing exosomes that are also health promoting.


Q: Do individuals who have recovered from COVID-19 also produce exosomes?

A: Every cell can produce exosomes throughout our lifetime. The mechanisms involved in exosome production are intimately linked to the moment-to-moment existence of cells.

About the Author

Kurt Woeller, DO, FMAPS

Kurt N. Woeller, DO, FMAPS, is a Doctor of Osteopathic Medicine, integrative and functional medicine physician, and biomedical Autism Treatment Specialist in clinical practice for over 25 years.

Dr. Woeller is the education director and main course developer for his Integrative Medicine Academy (https://integrativemedicineacademy.com), an online academy for health professionals. He is also the Organic Acids Test (OAT) seminar creator and presenter for Mosaic Diagnostics Laboratory (formally Great Plains Laboratory’s GPL Academy) Mosaic EDGE seminars and has been involved in monthly educational webinars for GPL/Mosaic Diagnostics, and other organizations for over a decade.

His private practice, Sunrise Functional Medicine (https://mysunrisecenter.com), focuses on specialized diagnostic testing and treatments for individuals with complex medical conditions like autism, autoimmune, gastrointestinal, certain neurological disorders, and other chronic health conditions. Dr. Woeller is a Fellow of the Medical Academy of Pediatric Special Needs (MAPS).

He has served as a clinical consultant for various laboratory companies, i.e., Great Plains Laboratory, BioHealth Laboratory, providing health practitioner education regarding functional and integrative medicine.

You can follow Dr. Woeller for ongoing education articles and videos through his Substack at https://drwoeller.substack.com/ and his YouTube channel for Integrative Medicine Academyhttps://www.youtube.com/@integrativemedicineacademy. Finally, listen to Dr. Woeller’s latest health professional interviews through his Functional Medicine Doc Talk Podcast – https://functionalmedicinedoctalk.com.