Q: Would this test reveal perturbations in thiamine status (sufficiency/deficiency, function, other), and if so — how?
A: Only as a reflection of lactic acid levels, and certain markers within the Amino Acid Metabolites (#62-#66).
Q: Would this test reveal perturbations in ALDEHYDE metabolism? Can it distinguish between exogenous exposure; excess endogenous formation; triggering of endogenous cellular defense mechanism; other…?
A: Arabinose (marker #7) is an aldehyde. Other organic acid structures could be checked for aldehyde status. There is always the possibility within certain markers biochemically that its elevation could be influenced by exogenous exposure, but a representative elevated acid could be triggered for multiple reasons. The OAT is not going to identify specifically exogenous aldehydes specifically that I am aware of.
Q: Would this test reveal the status of mitochondrial form and function?
A: The OAT does provide information about the function of mitochondrial activity.
Q: In other words, would it reveal the Healing and Aging Cycle stage? (ref RK Naviaux) Would it indicate changes in mitochondrial membrane permeability?
A: The OAT is not going to get that detailed into mitochondrial permeability. However, mitochondrial membrane disruption could be one reason OAT mitochondrial markers are elevated.
Q: What does elevated suberic acid imply?
A: This is commonly associated with a fasting state but could indicate poor cellular fat metabolism. Generally, the use of L-carnitine is helpful.
Q: Do you use plasma amino acids test along with Organic Acids Test for the information you talk about today? Can we see changes in plasma amino acids when OAT is abnormal?
A: It is possible to see plasma amino acid levels out of balance in relation to certain deficiency states or genetic influences on amino acid pathways.
Q: I am a bit confused if you said marker 31 is a Leucine or Lysine metabolite?
A: Markers #30 and #32 are linked to leucine, and marker #31 is linked to lysine.
